|
KMID : 0882420080750060658
|
|
Korean Journal of Medicine
2008 Volume.75 No. 6 p.658 ~ p.664
|
|
|
Thromboembolism during pregnancy or postpartum
|
|
Seo Yun-Yong
Yang Moon-Seok
Kim Do-Yi
Won Hyun-Sun
Lee Su-Hee
Hong Young-Ho
Kim Tae-Sun
Shin Hyun-Ho
Park Jeong-Bae
|
|
|
Abstract
|
|
|
Background/Aims: Venous thromboembolism (VTE) during pregnancy or postpartum is a major cause of maternal complications and death; however, the risk is uncertain. In this study, we sought to estimate the incidence of VTE during pregnancy and to identify risk factors for pregnancy-related VTE.
Methods: We retrospectively evaluated the incidence, risk factors, treatment, and prognosis for VTE based on 40,989 deliveries at Cheil General Hospital, Kwandong University College of Medicine, over a five-year period from February 2003 to January 2008. The risk factors were analyzed by χ2-analysis and forward stepwise logistic regression, and are presented as crude and adjusted odds ratios (ORs) with a 95% confidence interval (CI).
Results: The incidence of VTE was 0.042% (17 patients, mean age 32.4±2.5 years), with deep venous thrombosis (DVT) in 0.01% of the patients (4 patients, mean age 31.5±2.9 years), and pulmonary embolism (PE) in 0.032% of the patients (13 patients, mean age 32.6±2.5 years). The postnatal incidence of VTE was higher than the antenatal incidence (2 vs. 15). The main manifestations at the time of diagnosis, in order of frequency, were: dyspnea in 8 patients (62%), chest pain in 4 patients (31%), cough in 2 patients (15%), and syncope in 1 patient (8%). The risk factors for VTE were Cesarean section (OR=7.4; 95% CI: 2.1-25.7, p=0.002) and preeclampsia (OR=12.0; 95% CI: 4.2-34.2, p<0.000). All cases showed clinical improvement spontaneously, or with anticoagulation and surgical thrombectomy, and caused no fetal or maternal mortality.
Conclusions: The incidence of VTE during pregnancy was 0.042%; the independent risk factors were Cesarean section and preeclampsia. (Korean J Med 75:658-664, 2008)
|
|
|
KEYWORD
|
|
|
Pregnancy, Venous thromboembolism, Pulmonary embolism, Deep vein thrombosis
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|
|